Principle
The mid infrared wavelengths include fundamental vibration signatures of major molecules that compose the tissues and biological fluids. Therefore, the mid infrared light absorption spectrum of a biologic fluid is representative of its composition, as it accurately reflects the structure of the molecules constituting the sample. It provides a comprehensive metabolic profile.
It is then possible to classify the spectrum of measured samples relatively to healthy cases and pathological cases references. Infrared spectrum diagnosis score is based upon analysis of the entire molecular characteristics of the sample, and not based on the analysis of a small number of a priori identified markers.
DIAFIR is a compelling technology for recording and analyzing mid-infrared light patient blood serum signature, in order to provide diagnosis score within minutes.
SPID PLATFORM
HOW DOES IT WORKS ?
DIAFIR has developed the SPID™ platform, combining:
- patented mid-infrared light biosensor.
- dedicated spectroscopic device.
- proprietary machine learning algorithm allowing diagnosis score delivery within minutes.
step 1
Serum preparation from blood patient
step 2
Recording and analysis using our SPID™ platform.
step 3
Disease diagnosis delivery
key benefits
- Same-day detection of NASH with high sensitivity and specificity, enabling fast referral of patients for full diagnosis and treatment.
- Potential to replace invasive biopsies, decreasing operating risk and saving hospitalization costs.
- Ability to classify patients leading to significantly improved treatment options and patient outcomes.
- Safe, label-free, non-destructive analysis requiring no special training and minimal sample preparation.
- Potential as a companion diagnostic for precision medicine
Publications
- Anty R, Le Corvec M, Iannelli A, Patouraux S, Saint-Paul M-C, Schneck A-S, et al. Mid-Infrared Spectroscopy Has a High Sensitivity and Specificity for Point-Of-Care Diagnosis of Non-Alcoholic Steato-Hepatitis. J Hepatol 2016;64:S177. doi:10.1016/S0168-8278(16)00104-5.
- Anty R, Le Corvec M, Renou C, Raoult A, Nousbaum J-B, Tanne F, et al. Mid-Infrared Spectroscopy has a High Sensitivity and Specificity for Point-of-Care Diagnosis of Spontaneous Bacterial Peritonitis. J Hepatol 2016;64:S666–7. doi:10.1016/S0168-8278(16)01255-1.
- Le Corvec M, Charpentier F, Kachenoura A, Bensaid S, Henno S, Bardou-Jacquet E, et al. Fast and Non-Invasive Medical Diagnostic Using Mid Infrared Sensor. IRBM 2016;37:116–23. doi:10.1016/j.irbm.2016.03.003.
- Le Corvec M, Allain C, Lardjane S, Cavey T, Turlin B, Fautrel A, et al. Mid-infrared fibre evanescent wave spectroscopy of serum allows fingerprinting of the hepatic metabolic status in mice. The Analyst 2016;141:6259–69. doi:10.1039/C6AN00136J.
- Le Corvec M, Boussard-Plédel C, Charpentier F, Fatih N, Le Dare B, Massart F, et al. Chemotaxonomic discrimination of lichen species using an infrared chalcogenide fibre optic sensor: a useful tool for on-field biosourcing. RSC Adv 2016;6:108187–95. doi:10.1039/C6RA17140K.
- Albert J-D, Monbet V, Jolivet-Gougeon A, Fatih N, Le Corvec M, Seck M, et al. A novel method for a fast diagnosis of septic arthritis using mid infrared and deported spectroscopy. Joint Bone Spine 2016;83:318–23. doi:10.1016/j.jbspin.2015.05.009.
- Anne M-L, Le Lan C, Monbet V, Boussard-Plédel C, Ropert M, Sire O, et al. Fiber evanescent wave spectroscopy using the mid-infrared provides useful fingerprints for metabolic profiling in humans. J Biomed Opt 2009;14:054033. doi:10.1117/1.3253319.
- Keirsse J, Boussard-Plédel C, Loréal O, Sire O, Bureau B, Leroyer P, et al. IR optical fiber sensor for biomedical applications. Vib Spectrosc 2003;32:23–32. doi:10.1016/S0924-2031(03)00044-4.
- Hocdé S, Boussard-Plédel C, Fonteneau G, Lecoq D, Ma H-L, Lucas J. Recent developments in chemical sensing using infrared glass fibers. J Non-Cryst Solids 2000;274:17–22. doi:10.1016/S0022-3093(00)00179-4.